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Only with a good protected mode/vm86 extender (I don't know if any supports x86-64) and a fast enough compiler (dunno if djgpp supports recent gcc builds either).
But for direct hw manipulation and realtime tasks (remember all those vga scrollers, demos relying on vertical& horizontal retrace for their effects), DOS can hardly be matched 
Then you *HAVE* to check this out. http://www.japheth.de/HX.html
Its like Win32s for dos! Its really cool!
Python also has a complete and functioning DOS port. See http://www.caddit.net/pythond.php
Out of curiosity, I downloaded OpenGEM and ran its install.bat from an XP command prompt. After it littered my C: drive with about 5 new directories and gem.bat in the root directory (ah, the good old days) I typed in 'gem.bat', and lo and behold, it worked. Not terribly functional, but still fun to play with for a few minutes.





