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Many distros that ran PPC, but slowly, OOtB, like Ubuntu, would also have random packages that wouldn't work. I'm sure this is why things like MorphOS can stay around.
Until 99% of our software is written with managed languages, which do not allow you to do low-level work on memory addressing, or rely on a specific endianness, or other such things, I doubt the situation will change much, because there is too much required testing, and not enough people and time to do it for every package. Edited 2010-03-29 19:17 UTC