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Assuming the base and kernel is left untouched (from FreeBSD), it's likely you will have problems with PC-BSD... The 7.x series has an issue with Apple USB keyboards (on macbooks at least) and 8.0, 8.1-RC2 as well as 9.0-CURRENT will not boot; failing on an ACPI error (disabling ACPI at the loader presents a different boot problem).
I'm still waiting for a realistic solution on http://forums.freebsd.org/showthread.php?t=12289&page=1 if you'd like to be kept up-to-date on the issue.
(I have a macbook 6,1) Edited 2010-07-22 02:12 UTC