Unix was originally all about not being... Multics. If Mono is to follow a similar nomenclature (just for the kicks), we have to talk about Mono's upcoming 'monopolization' and 'monarchy' in the next generation of the Unix programming land. Your see, if everything goes well, in 2 to 3 years most new Gnome user/desktop applications will be written --hopefully-- in Mono and C#. Update: Miguel deIcaza replies.
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No kernel patches needed. All you need is support for BINFMT_MISC compiled as a module and small script run during system start up.
Here are sources for debian package:
http://www.debianplanet.org/mono/dists/unstable/main/source/admin/
I believe they can be easily adapted to any distro.