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Praytell, how do you "optimize" for 64-bit processors?
By designing your huge-dataset algorithms around being able to address, day, each cell in a volume reconstruction, instead of using a technique similar to overlays from the old 16-bit days.
Even in "common" tasks like video editing, 32 bit addressing has reached its limits. It's not for nothing that serious file systems have 64 bit off_t's; but it would be cool to be able to mmap() such a file...