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I remember doing amazing things with Desqview under DOS. Yes, it wasn't GUI. However it ran all the programs I needed to run plus a two line Fidonet BBS.
I remember seeing a demo of Desqview X at one of the big computer shows back around '92 or '93. It rocked (mostly because it was a DOS port of X Windows) but Quarterdeck dropped the ball and couldn't get it out for 4 or 5 years. By then Windows95 had taken hold. Sometimes I wonder what would have happened if they could have gotten it out right away.