The Mac platform was always considered a premium platform, hence much of its software is shareware or commercial. In the recent days more freeware applications have emerged, but the majority are small utilities and not full scale applications. Enter the world of GNU which can not only provide "free" applications as in beer, but most importantly, "Free", as in Freedom.
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Removing Python apps from your list because you need to install another wrapper is ridiculous if you consider that Inkscape uses GTKmm.